Key result
Elevated serum Beta-trace protein levels were independently associated with the presence of paroxysmal atrial fibrillation in patients with controlled hypertension (OR 1.015; P<.001).
Why the study?
Are elevated serum Beta-trace protein levels associated with the presence of paroxysmal atrial fibrillation in patients with controlled hypertension?
Case-Control (n=160)
Are elevated serum Beta-trace protein levels associated with the presence of paroxysmal atrial fibrillation in patients with controlled hypertension?
Elevated serum Beta-trace protein levels are independently associated with paroxysmal atrial fibrillation in hypertensive patients with normal renal function.
Hypothesis-generating for beta-trace protein as AF biomarker in hypertension; prospective validation required before clinical use.
Beta-trace protein (BTP) has emerged as a novel biomarker of cardiovascular risk. In this study, the authors aimed to assess the relationship between BTP levels and presence of atrial fibrillation in patients who had controlled hypertension (HTN) and normal renal function. A total of 80 controlled HTN patients with paroxysmal atrial fibrillation (PAF) and 80 age- and sex-matched controls with controlled HTN were enrolled. Serum BTP levels were measured by enzyme-linked immunosorbent assay. BTP levels were found to be significantly higher in patients with PAF (P<.001). Other parameters including mean systolic and diastolic blood pressure values, serum creatinine levels, and glomerular filtration rate were similar between the two groups. Along with left atrial diameter (odds ratio, 1.504; P<.001), BTP levels (odds ratio, 1.015; P<.001) were independently associated with the presence of PAF. BTP levels were increased in controlled HTN patients with PAF compared with controls, and this association was observed within normal renal functions as reflected by normal glomerular filtration rate.
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Yalçın et al. (2015) conducted a case-control in Controlled hypertension with or without paroxysmal atrial fibrillation (n=160). Serum Beta-trace protein (BTP) levels vs. Controls with controlled hypertension was evaluated on Presence of paroxysmal atrial fibrillation (OR 1.015, p=<.001). Elevated serum Beta-trace protein levels were independently associated with the presence of paroxysmal atrial fibrillation in patients with controlled hypertension (OR 1.015; P<.001).
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