Key result
Epicardial left atrial appendage occlusion significantly decreased most clotting factors at 6 months compared to baseline, particularly in patients with normal LAA body and orifice diameter size.
Why the study?
Left atrial appendage occlusion affects systemic coagulation parameters, but differences in coagulation factor changes based on varying LAA morphometries had not been investigated in detail.
Does epicardial left atrial appendage occlusion improve systemic coagulation parameters at 6 months in patients undergoing the procedure?
Observational (n=22)
Does epicardial left atrial appendage occlusion improve systemic coagulation parameters at 6 months in patients undergoing the procedure?
Epicardial left atrial appendage occlusion is associated with beneficial reductions in systemic coagulation factors at 6 months, particularly in patients with normal LAA size.
Coagulation changes after epicardial LAAO vary by morphology; hypothesis-generating and requires validation before clinical consideration.
Left atrial appendage occlusion affects systemic coagulation parameters, leading to additional patient-related benefits. The aim of this study was to investigate the differences in coagulation factor changes 6 months after epicardial left atrial appendage occlusion in patients with different LAA morphometries. This is the first study to analyze these relationships in detail. A prospective study of 22 consecutive patients was performed. Plasminogen, fibrinogen, tPA concentration, PAI-1, TAFI and computed tomography angiograms were performed. Patients were divided into subgroups based on left atrial appendage body and orifice diameter enlargement. The results of blood tests at baseline and six-month follow-up were compared. In a population with normal LAA body size and normal orifice diameter size, a significant decrease in analyzed clotting factors was observed between baseline and follow-up for all parameters except plasminogen. A significant decrease between baseline and follow-up was observed with enlarged LAA body size in all parameters except TAFI, in which it was insignificant and plasminogen, in which a significant increase was observed. Occlusion of the left atrial appendage is beneficial for systemic coagulation. Patients with a small LAA may benefit more from LAA closure in terms of stabilizing their coagulation factors associated with potential thromboembolic events in the future.
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Batko et al. (2023) conducted an observational in Patients undergoing epicardial left atrial appendage occlusion (n=22). Epicardial left atrial appendage occlusion vs. Baseline (pre-occlusion) was evaluated on Changes in coagulation factors (plasminogen, fibrinogen, tPA concentration, PAI-1, TAFI) at 6 months. Epicardial left atrial appendage occlusion significantly decreased most clotting factors at 6 months compared to baseline, particularly in patients with normal LAA body and orifice diameter size.
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