July 1, 1998The Journal of PhysiologyOpen Access

K+ channel block‐induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation

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Population

Neuroblastoma x glioma hybrid NG108-15 cells

Comparison

K+ channel blockers, osmolarity changes, Cl… vs Control conditions (standard culture medium)

Design

Preclinical

Authors

BRB�atrice Rouzaire-DuboisCentre National de la Recherche Scientifique JDJean‐Marc DuboisUniversité Paris-Sud

Discussion

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Implication

No clinical translation for neuroblastoma yet; leaves open cell volume as a mitogenic regulator in preclinical models.

Structured PICO

Population

Neuroblastoma x glioma hybrid NG108-15 cells

Intervention

K+ channel blockers (TEA 1-10 mM, 4-aminopyridine 0.2-2 mM, Cs+ 2.5-10 mM), osmolarity changes, Cl- channel blocker (NPPB), and antibiotics

Comparator

Control conditions (standard culture medium)

Outcome

Cell volume and rate of cell proliferationsurrogate

K+ channel blockers induce cell swelling and inhibit proliferation in neuroblastoma cells, suggesting that cell volume regulation is a key mechanism in mitogenesis.

Cite This Study

Rouzaire-Dubois et al. (1998) studied this question.

synapsesocial.com/papers/6a7ca0a3a84850a1a3a8b00a https://doi.org/10.1111/j.1469-7793.1998.093bz.x

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K+ channel block‐induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

K+ channel block‐induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider