Population
Human 1321N1 astrocytoma cells
Comparison
Specific BK channel blockers iberiotoxin or 1 mM… vs Cells exposed to physiological external [K+] of…
Design
Preclinical
Authors
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BK channel blockade may curb astrocytoma growth in vitro; leaves open whether this extends to in vivo models or clinical translation.
BK channel blockers abolish potassium-induced proliferation in human astrocytoma cells, suggesting a role for BK channels in tumor growth.
Basrai et al. (2002) studied this question.
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