Key result
Although pharmacological inhibitors of BK and IK1 channels reduced glioma cell proliferation at high concentrations, specific siRNA knockdown of these channels did not affect proliferation rates, indicating they do not play a critical role in glioma cell growth.
Population
Human glioblastoma cells
Comparison
Pharmacological inhibitors of BK and IK1… vs Control (implied)
Design
Preclinical
Authors
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Suggests off-target actions of BK/IK1 inhibitors in glioma; leaves open channel roles in vivo.
Ca(2+)-activated K(+) channels do not play a critical role in the proliferation of glioma cells, and the antiproliferative effects of their pharmacological inhibitors are likely due to off-target actions.
Abdullaev et al. (2010) studied Glioblastoma multiforme. BK and IK1 channel inhibitors and gene-specific siRNAs vs. Vehicle control or negative control siRNA was evaluated on Cell proliferation rate. Although pharmacological inhibitors of BK and IK1 channels reduced glioma cell proliferation at high concentrations, specific siRNA knockdown of these channels did not affect proliferation rates, indicating they do not play a critical role in glioma cell growth.
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