Why the study?
Does BK channel inhibition by iberiotoxin reduce tumor growth in human malignant glioma cells under serum-free conditions?
Population
Human malignant glioma cells
Comparison
Iberiotoxin under serum-free conditions vs Untreated cells or cells maintained in 7% fetal…
Design
Preclinical
Follow-up
4-5 days
Authors
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May impair glioma viability during growth factor deprivation; leaves open gBK targeting for human tumors.
Does BK channel inhibition by iberiotoxin reduce tumor growth in human malignant glioma cells under serum-free conditions?
BK channel inhibition by iberiotoxin reduces glioma cell growth under serum-free conditions, suggesting functional gBK channels promote tumor cell growth during growth factor deprivation.
Weaver et al. (2004) studied this question.
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