October 1, 1986Journal of Hypertension
Circadian Rhythm of Plasma Renin Activity in Older Normal and Essential Hypertensive Men: Relation with Inactive Renin, Aldosterone, Cortisol and REM Sleep
Why the study?
Do the circadian rhythms and levels of plasma renin activity, inactive renin, aldosterone, and cortisol differ between older normal men and those with essential hypertension?
Population
25 men older than 55 years, comprising 13 normal men and 12 patients with essential hypertension.
Comparison
24-hour monitoring of plasma renin activity… vs Normal normotensive men compared to men with…
Design
Cross-sectional
Follow-up
24 hours
Authors
Discussion
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Implication
May suggest adrenal hypersensitivity in older hypertensives; leaves open causality and clinical utility of renin profiling.
Structured PICO
Do the circadian rhythms and levels of plasma renin activity, inactive renin, aldosterone, and cortisol differ between older normal men and those with essential hypertension?
P
Population
25 men older than 55 years, comprising 13 normal men and 12 patients with essential hypertension.
I
Intervention
24-hour monitoring of plasma renin activity (PRA), inactive renin (IR), plasma aldosterone (PA), and cortisol, with blood sampling every 2 hours during the day and every 30 minutes at night, alongside sleep monitoring.
C
Comparator
Normal normotensive men compared to men with essential hypertension.
O
Outcome
24-hour pattern and mean levels of plasma renin activity (PRA), inactive renin (IR), plasma aldosterone (PA), and cortisol.surrogate
Older men with essential hypertension exhibit lower mean plasma renin activity and inactive renin levels over 24 hours compared to normotensive peers, with a higher aldosterone-to-renin ratio suggesting increased adrenal sensitivity to angiotensin II.
Cite This Study
Stern et al. (1986) studied this question.