Why the study?
Do fluorescent SSCP and denaturing HPLC analysis provide comparable diagnostic accuracy to direct sequencing for mutation screening in hypertrophic cardiomyopathy?
Population
Patients with hypertrophic cardiomyopathy undergoing genetic mutation screening
Comparison
Fluorescent single strand conformation… vs Direct sequencing
Design
Other
Authors
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F-SSCP and DHPLC may aid HCM mutation screening; leaves open equivalence to direct sequencing.
Do fluorescent SSCP and denaturing HPLC analysis provide comparable diagnostic accuracy to direct sequencing for mutation screening in hypertrophic cardiomyopathy?
This study evaluates the diagnostic accuracy of F-SSCP and DHPLC compared to direct sequencing for genetic mutation screening in hypertrophic cardiomyopathy.
Jens Mogensen (2003) studied this question.