What question did this study set out to answer?

To determine whether sympathetic nervous stimulation to the heart during exercise changes with increasing age.

October 1, 1971Cardiovascular Research

Sympathetic nervous activity during exercise in relation to age

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Why the study?

Does the effect of propranolol on heart rate and cardiac output during exercise differ between older and younger subjects?

Population

Older (50-65 yr) and younger (20-35 yr) subjects

Design

Other

Authors

JCJames ConwayAstraZeneca (United Kingdom)RWRichard WheelerInstitut Pasteur RSR SannerstedtLinköping University

Discussion

Member takes

Implication

May warrant age-adjusted expectations for propranolol during exercise; leaves open confirmation in prospective trials.

Key Points

To determine whether sympathetic nervous stimulation to the heart during exercise changes with increasing age.
Assessed exercise hemodynamics in younger individuals (aged 20–35 years) compared to older individuals (aged 50–65 years).
Administered the beta-adrenergic antagonist propranolol to measure the degree of heart rate and cardiac output reduction during physical exertion.
Propranolol decreased heart rate and cardiac output during exercise across all participants.
The magnitude of reduction in heart rate and cardiac output was smaller in older subjects than in younger subjects, indicating an age-associated decline in sympathetic drive.

Structured PICO

Does the effect of propranolol on heart rate and cardiac output during exercise differ between older and younger subjects?

Population

Older (50-65 yr) and younger (20-35 yr) subjects

Intervention

Propranolol during exercise

Outcome

Heart rate and cardiac output during exercisesurrogate

The sympathetic drive to the heart elicited by exercise appears to decline with age, as evidenced by a blunted physiological response to propranolol in older individuals.

Cite This Study

Conway et al. (1971) studied this question.

synapsesocial.com/papers/6a7ca45652489361ef8ce31d https://doi.org/10.1093/cvr/5.4.577

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Sympathetic nervous activity during exercise in relation to age

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Sympathetic nervous activity during exercise in relation to age

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider