Population
Murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in Chinese hamster ovary…
Comparison
Protein kinases and phosphatases vs Baseline conditions or inactive enantiomers…
Design
Preclinical
Authors
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Caution against extrapolating murine CFTR data to human disease; leaves open the role of subconductance states in species-specific regulation.
Differences in channel regulation between human and murine CFTR may be explained by the occupancy of a very small subconductance state in murine CFTR.
Lansdell et al. (1998) studied this question.
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