July 1, 1992British Journal of PharmacologyOpen Access

An endothelial 5‐HT receptor that mediates relaxation in guinea‐pig isolated jugular vein resembles the 5‐HT1D subtype

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Population

Guinea-pig isolated jugular vein preparation

Design

Preclinical

Authors

PGPaul GuptaPfizer (United States)

Discussion

Member takes

Implication

May inform endothelial 5-HT pharmacology in animal models; leaves open human translation and therapeutic relevance.

Structured PICO

Population

Guinea-pig isolated jugular vein preparation

Intervention

5-HT receptor agonists (including 5-HT, 5-CT, sumatriptan) and antagonists

Outcome

Endothelium-dependent and -independent relaxationssurrogate

The endothelial 5-HT receptor mediating relaxation in the guinea-pig jugular vein exhibits pharmacological characteristics consistent with the 5-HT1D subtype.

Cite This Study

Paul Gupta (1992) studied this question.

synapsesocial.com/papers/6a7ca545fd7ae2306b770e7b https://doi.org/10.1111/j.1476-5381.1992.tb14398.x

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Ask AI

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An endothelial 5‐HT receptor that mediates relaxation in guinea‐pig isolated jugular vein resembles the 5‐HT1D subtype

Discussion

Member takes

Implication

Structured PICO

Cite This Study

An endothelial 5‐HT receptor that mediates relaxation in guinea‐pig isolated jugular vein resembles the 5‐HT1D subtype

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider