January 1, 1994The Japanese Journal of PharmacologyOpen Access

Characterization of 5-Hydroxytryptamine Receptors on the Isolated Pig Basilar Artery by Functional and Radioligand Binding Studies

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Population

Isolated pig basilar arteries

Design

Preclinical

Authors

AMAtsushi MiyamotoKagoshima University TSToyoaki Sakota ANAkira NishioOsaka Hospital

Discussion

Member takes

Implication

Characterizes 5-HT1/2 receptors on porcine basilar smooth muscle; hypothesis-generating for human cerebrovascular vasomotor control.

Structured PICO

Population

Isolated pig basilar arteries

Intervention

5-Hydroxytryptamine (5-HT) agonists (5-carboxamidotryptamine, 5-HT, α-methyl-5-HT, (±)-8-hydroxydipropylaminotetralin) and antagonists (ketanserin, methiothepin)

Outcome

Contractile responses and radioligand binding affinities (Kd, Bmax)surrogate

Both 5-HT1 and 5-HT2 receptors are present on pig basilar arterial smooth muscle cells and their stimulation results in contraction.

Cite This Study

Miyamoto et al. (1994) studied this question.

synapsesocial.com/papers/6a88030decbb6f2effa53061 https://doi.org/10.1016/s0021-5198(19)35758-0

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Characterization of 5-Hydroxytryptamine Receptors on the Isolated Pig Basilar Artery by Functional and Radioligand Binding Studies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of 5-Hydroxytryptamine Receptors on the Isolated Pig Basilar Artery by Functional and Radioligand Binding Studies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider