March 1, 1988British Journal of PharmacologyOpen Access

5‐Hydroxytryptamine‐induced tachycardia in the pig: possible involvement of a new type of 5‐hydroxytryptamine receptor

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Population

Pentobarbitone-anaesthetized pigs (n=39 for intravenous bolus, n=4 for topical application)

Design

Preclinical

Authors

ABA. BomVrije Universiteit Brussel DDDirk J. DunckerGeneral Cardiology PSP.R. SaxenaNoida International University

Discussion

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Implication

May support a novel 5-HT receptor mediating porcine tachycardia; leaves open translation to human physiology or therapy.

Structured PICO

Population

Pentobarbitone-anaesthetized pigs (n=39 for intravenous bolus, n=4 for topical application)

Intervention

5-hydroxytryptamine (5-HT) via intravenous bolus (3, 10, 30 micrograms kg-1) or topical application, tested with various receptor antagonists and agonists

Outcome

Heart rate (positive chronotropic effect)surrogate

Tachycardia induced by 5-HT in the pig is likely mediated by a novel 5-HT receptor type distinct from 5-HT1-like, 5-HT2, or 5-HT3 receptors.

Cite This Study

Bom et al. (1988) studied this question.

synapsesocial.com/papers/6a7aa86f02ab7a73dd0306b6 https://doi.org/10.1111/j.1476-5381.1988.tb10324.x

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5‐Hydroxytryptamine‐induced tachycardia in the pig: possible involvement of a new type of 5‐hydroxytryptamine receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

5‐Hydroxytryptamine‐induced tachycardia in the pig: possible involvement of a new type of 5‐hydroxytryptamine receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider