Key result
Tryptamine and benzamide derivatives dose-dependently increased porcine heart rate (e.g., 5-HT increased heart rate by 25 to 68 beats/min), mediated by a putative 5-HT4 receptor.
Population
Anaesthetized pigs
Design
Preclinical
Authors
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Porcine 5-HT4 chronotropy data remain preclinical; leaves open human translation and therapeutic relevance.
Tryptamine and benzamide derivatives increase porcine heart rate by a direct action on the cardiac pacemaker via the activation of a putative 5-HT4 receptor.
Villalón et al. (1991) studied this question. Tryptamine and benzamide derivatives was evaluated on Heart rate. Tryptamine and benzamide derivatives dose-dependently increased porcine heart rate (e.g., 5-HT increased heart rate by 25 to 68 beats/min), mediated by a putative 5-HT4 receptor.
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