Why the study?
Does IVth ventricular administration of tryptamine analogues alter autonomic outflow compared to 8-OH-DPAT in anaesthetized cats?
Population
Cats which were anaesthetized with a mixture of alpha-chloralose and pentobarbitone sodium, neuromuscularly…
Comparison
IVth ventricular application of tryptamine… vs 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
Design
Preclinical
Authors
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Supports brainstem 5-HT1A-mediated sympathoinhibition in cats; extends prior IV data but leaves human translation open.
Does IVth ventricular administration of tryptamine analogues alter autonomic outflow compared to 8-OH-DPAT in anaesthetized cats?
Brainstem 5-HT1A receptors are involved in central sympathoinhibitory effects and control of renal sympathetic outflow, while selective tryptamine agonists differ from non-tryptamine agonists by not increasing central cardiac vagal tone.
Shepheard et al. (1994) studied this question.
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