Influence of 5-HT1A Receptor Agonists on Sympathetic and Parasympathetic Nerve Activity

View Full Paper

Ask AI

Bookmark

Comparison

5-HT1A receptor agonists (e.g., 8-OH-DPAT) vs alpha 2-adrenoceptor agonists (e.g., clonidine)

Design

Review

Authors

Discussion

Does not alter management; leaves open therapeutic targeting of 5-HT1A receptors in autonomic cardiovascular disorders.

Intervention

5-HT1A receptor agonists (e.g., 8-OH-DPAT)

Comparator

alpha 2-adrenoceptor agonists (e.g., clonidine)

Outcome

Sympathetic and parasympathetic nerve activitysurrogate

5-HT1A receptor agonists modulate central cardiovascular pathways by causing differential sympathoinhibition and increasing cardiac vagal drive.

Andrew G. Ramage (1990) studied this question.

View Full Paper

Ask AI

Bookmark