Key result
5-HT elicits tachycardia in the pig by acting on a novel receptor similar to the 5-HT4 receptor, with responses antagonized by ICS 205-930.
Population
Anaesthetized pigs
Design
Preclinical
Authors
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Findings in porcine model warrant caution before clinical extrapolation; leaves open validation of 5-HT4-like receptors in human cardiac tissue.
5-HT induces tachycardia in pigs through a receptor similar or identical to the 5-HT4 receptor.
Villalón et al. (1990) studied this question. 5-hydroxytryptamine (5-HT) was evaluated on Increase in heart rate. 5-HT elicits tachycardia in the pig by acting on a novel receptor similar to the 5-HT4 receptor, with responses antagonized by ICS 205-930.
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