Key result
5-HT stimulates a short-circuit current response in rat colon via a receptor mechanism selectively antagonized by ICS 205-930, metoclopramide, and cisapride, exhibiting properties of the 5-HT4 receptor.
Population
Rat isolated colonic mucosa
Design
Preclinical
Authors
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Supports 5-HT4 mediation of rat colonic ion transport; leaves open translation to human motility or secretory disorders.
The study identifies that the 5-HT receptor mediating short-circuit current in rat colon exhibits properties of the 5-HT4 receptor.
Bunce et al. (1991) studied this question. 5-Hydroxytryptamine (5-HT) was evaluated on Short-circuit current (SCC) response. 5-HT stimulates a short-circuit current response in rat colon via a receptor mechanism selectively antagonized by ICS 205-930, metoclopramide, and cisapride, exhibiting properties of the 5-HT4 receptor.
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