Why the study?
Does amlodipine compared to nifedipine retard differentially affect autonomic nerve activity and heart rate in patients with essential hypertension?
Population
20 patients (6 men, 14 women; mean age 63 +/- 2 years) with essential hypertension.
Comparison
Amlodipine (2.5 or 5 mg once daily) for 4 weeks. vs Nifedipine retard for 4 weeks and a 4-week…
Design
RCT, The order of the three periods was randomized.
Follow-up
4 weeks per treatment period
Authors
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May warrant preferring amlodipine over nifedipine retard to avoid reflex sympathetic activation; confirms differential autonomic effects among dihydropyridines.
Does amlodipine compared to nifedipine retard differentially affect autonomic nerve activity and heart rate in patients with essential hypertension?
Unlike nifedipine retard, amlodipine lowers blood pressure without causing reflex tachycardia or sympathetic activation in patients with essential hypertension.
Minami et al. (1998) studied this question.
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