Why the study?
Does first-dose doxorubicin administration worsen or induce ventricular arrhythmias in oncologic patients?
Population
30 oncologic patients receiving first-dose doxorubicin
Comparison
First-dose doxorubicin administration vs Pre-treatment baseline
Design
Cohort
Follow-up
24 hours after administration
Authors
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May support arrhythmia safety of first-dose doxorubicin; leaves open larger prospective validation before changing monitoring.
Does first-dose doxorubicin administration worsen or induce ventricular arrhythmias in oncologic patients?
First-dose doxorubicin does not appear to worsen antecedent ventricular ectopy or cause life-threatening arrhythmias in the first 24 hours, despite some new-onset premature ventricular contractions.
Friess et al. (1985) studied this question.
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