Implantation of an automatic cardioverter-defibrillator can effectively manage doxorubicin-induced ventricular arrhythmias, enabling patients to safely continue essential chemotherapy.
Answers are grounded in this paper and cite their sources.
May support ICD implantation to continue chemotherapy in doxorubicin-induced arrhythmias; leaves open need for prospective validation.
Anthracyclines are a group of potent antitumour agents and cardiotoxicity is an important factor limiting their therapeutic effectiveness. Although cardiomyopathy is the most widely recognized type of cardiotoxic reaction, early arrhythmia following anthracycline administration may be of clinical significance as well. We report a case of ventricular tachycardia causing cardiac arrest in a female treated with doxorubicin as adjuvant therapy of breast cancer. Due to recurrence of the arrhythmia and a desire to continue chemotherapy, an automatic cardioverter-defibrillator was implanted with excellent effect.
No takes yet. Share an insight, caveat, or question.
Rudziński et al. (2007) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: