What question did this study set out to answer?

To evaluate the long-term effect of intensive versus conventional diabetes therapy on the incidence and cost of ocular surgical procedures in individuals with type 1 diabetes.

April 29, 2015New England Journal of MedicineOpen Access

Intensive Diabetes Therapy and Ocular Surgery in Type 1 Diabetes

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To evaluate the long-term effect of intensive versus conventional diabetes therapy on the incidence and cost of ocular surgical procedures in individuals with type 1 diabetes.
Randomized clinical trial (DCCT, NCT00360893/NCT00360815) in which 1441 patients with type 1 diabetes received either intensive therapy or conventional therapy between 1983 and 1993.
Long-term follow-up of 1375 participants through the observational EDIC study, tracking self-reported ocular surgical history annually over a median follow-up of 23 years.
Ocular surgery was performed in 63 of 711 patients (8.9%, 130 operations) with intensive therapy versus 98 of 730 patients (13.4%, 189 operations) with conventional therapy (P<0.001), representing a 48% adjusted risk reduction for any diabetes-related ocular surgery (95% CI, 29 to 63; P<0.001).
Intensive therapy reduced the adjusted risk of cataract extraction by 48% (42 vs. 61 patients; 95% CI, 23 to 65; P=0.002) and vitrectomy or retinal-detachment surgery by 45% (29 vs. 50 patients; 95% CI, 12 to 66; P=0.01).
Surgical costs were 32% lower in the intensive-therapy cohort, with clinical benefits fully attenuated after adjusting for mean glycated hemoglobin levels over follow-up.

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Implication

Randomized trial shows intensive glycemic control reduces ocular surgery risk and costs in type 1 diabetes, indicating durable protection through long-term blood glucose regulation.

Cite This Study

A 2015 study studied this question.

synapsesocial.com/papers/6a7ca5eddd4ac9e48f1909e9 https://doi.org/10.1056/nejmoa1409463

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Implication

Randomized trial shows intensive glycemic control reduces ocular surgery risk and costs in type 1 diabetes, indicating durable protection through long-term blood glucose regulation.

Intensive Diabetes Therapy and Ocular Surgery in Type 1 Diabetes

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Discussion

Implication

Cite This Study

Intensive Diabetes Therapy and Ocular Surgery in Type 1 Diabetes

Key Points

Discussion

Implication

Cite This Study

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