Why the study?
Does intravenous caldaret improve infarct size or ejection fraction in patients with large acute STEMI undergoing primary PCI?
Does intravenous caldaret improve infarct size or ejection fraction in patients with large acute STEMI undergoing primary PCI?
Intravenous caldaret administered prior to primary PCI for large STEMI is safe but does not reduce infarct size or improve ejection fraction.
Answers are grounded in this paper and cite their sources.
Caldaret does not reduce infarct size or improve EF in STEMI; challenges prior cardioprotective hypotheses and redirects research to alternative targets.
AIMS: To examine the safety and efficacy of intravenous caldaret in patients with large acute ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). METHODS AND RESULTS: STEMI patients (n=387) with > or =10 mm summed ST-deviation on electrocardiogram were randomized to receive a 48 h infusion of caldaret 57.5 mg [lower dose (LD)], caldaret 172.5 mg [higher dose (HD)], or placebo, starting before PCI. Both HD and LD were well tolerated. In 247 patients with pre-PCI TIMI 0/1, there was no effect of HD or LD on single photon emission computed tomography infarct size or ejection fraction assessed at Day 7 and Day 30. Subgroup analyses suggest that future work in patients with anterior MI might be warranted. CONCLUSION: This first human experience with caldaret prior to direct PCI for large STEMI shows a good safety profile. No evidence of efficacy was discerned. Subgroup analyses in anterior MI patients showed some effects in endpoints studied, however, these findings require confirmation in a further study if a drug effect is to be established.
No takes yet. Share an insight, caveat, or question.
Bär et al. (2006) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: