Key result
In patients with recurrent adrenocortical carcinoma, no surgery was associated with significantly shorter progression-free survival compared to microscopically complete resection (HR 3.4; 95% CI 1.6-7.0).
Why the study?
Does repeated surgery improve progression-free and overall survival in patients with recurrent adrenocortical carcinoma?
Population
154 patients with first recurrence after initial radical resection from the German Adrenocortical Carcinoma…
Comparison
Repeated surgery (radical resection) vs No surgery or macroscopically incomplete resection
Design
Cohort
Authors
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May support complete re-resection in recurrent adrenocortical carcinoma; leaves open randomized confirmation of survival benefit.
Cohort (n=154)
Yes
Does repeated surgery improve progression-free and overall survival in patients with recurrent adrenocortical carcinoma?
Hazard Ratio: 3.4 (95% CI 1.6–7)
In patients with recurrent adrenocortical carcinoma, complete resection and a time to first recurrence over 12 months are the best predictors of prolonged survival.
Erdogan et al. (2012) conducted a cohort in Recurrent Adrenocortical Carcinoma (n=154). No surgery vs. Microscopically complete (R0)-resection was evaluated on Progression-free survival (HR 3.4, 95% CI 1.6-7.0). In patients with recurrent adrenocortical carcinoma, no surgery was associated with significantly shorter progression-free survival compared to microscopically complete resection (HR 3.4; 95% CI 1.6-7.0).
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