Why the study?
Does metoprolol delay heart failure and improve cardiac function in rats with monocrotaline-induced pulmonary artery hypertension?
Population
Rats with monocrotaline-induced pulmonary artery hypertension (PAH) and right ventricular failure
Comparison
Metoprolol 10 mg/kg/day vs Vehicle
Design
Preclinical
Follow-up
up to 31 days
Authors
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Supports metoprolol in experimental PAH right heart failure; leaves open clinical translation pending human trials.
Does metoprolol delay heart failure and improve cardiac function in rats with monocrotaline-induced pulmonary artery hypertension?
In a rat model of PAH, metoprolol delayed the onset of right heart failure and improved right ventricular myocyte calcium handling and contractility.
Fowler et al. (2018) studied this question.
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