Why the study?
Are older age and male sex associated with higher cerebrovascular impedance?
Are older age and male sex associated with higher cerebrovascular impedance?
Older age and male sex are associated with higher cerebrovascular impedance, which may buffer systemic arterial pressure fluctuations but increase brain hypoperfusion risk.
May increase hypoperfusion risk in older adults and men; novel finding leaves open clinical relevance.
Impedance modulus at the first harmonics of cerebral blood flow velocity (CBFV) and carotid artery pressure oscillations (Z 1 ) was higher in the old (>64 yr) than in the young individuals (<45 yr), and it was higher in men than in women. Z 1 is negatively associated with CBFV after adjustment for age, sex, and body mass index. Increases in cerebrovascular impedance with age may buffer systemic arterial pressure fluctuations at the cost of increased brain hypoperfusion risk.
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Sugawara et al. (2020) studied this question.
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