As retinal changes usually precede the development of diabetic nephropathy, in the five patients with proteinuria but without retinopathy (three positive and two negative for chlorpropamide- alcohol flushing) the proteinuria may possibly have been due to other causes. If these cases are excluded the difference between the groups positive and negative for flushing becomes greater (1/191 (0 5 ) v 12/100 (120;).
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C H Twort (1981) studied this question.
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