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June 1, 1975Journal of Biological ChemistryOpen Access

The calcium and magnesium binding sites on troponin and their role in the regulation of myofibrillar adenosine triphosphatase.

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Population

Purified troponin (Tn) and its subunits (TnC, TnI, TnT)

Design

Preclinical

Authors

JPJohn D. PotterBroad Institute

Discussion

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Overview

No immediate clinical implications from animal data; leaves open translation of troponin cation binding to human cardiac regulation.

Structured PICO

P
Population
Purified troponin (Tn) and its subunits (TnC, TnI, TnT)
I
Intervention
Calcium and magnesium binding at various concentrations
O
Outcome
Binding constants and sites for Ca2+ and Mg2+ on troponin and TnC, and myofibrillar ATPase activitysurrogate

The study characterizes the specific calcium and magnesium binding sites on troponin, demonstrating that full activation of myofibrillar ATPase requires calcium binding to the calcium-specific sites rather than the competitive calcium-magnesium sites.

Cite This Study

John D. Potter (1975) studied this question.

synapsesocial.com/papers/6a7caef0a42cae215d7cd2bchttps://doi.org/10.1016/s0021-9258(19)41347-1
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Purification and Properties of the Components from Troponin1973 · 332 citations
  2. 2The effect of calcium on the force‐velocity relation of briefly glycerinated frog muscle fibres1971 · 261 citations
  3. 3On the Role of Heme in the Formation of the Structure of Cytochrome c1973 · 392 citations
  4. 4Stabilization of the globular structure of ferricytochrome c by chloride in acidic solvents1975 · 87 citations