Population
Wiskott Aldrich syndrome protein fragments expressed in Escherichia coli or obtained from proteolysis
Design
Preclinical
Authors
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Findings in recombinant systems warrant caution extrapolating to intact cells; leaves open flanking sequences' role in WASP-Cdc42 regulation.
The GBD/CRIB motif in WASP is necessary but not sufficient for tight binding to Cdc42, requiring regions outside this motif for structure formation and tight interaction.
Rudolph et al. (1998) studied this question.
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