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November 1, 1997Circulation Research

Increased Expression of Interleukin-1β and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Hypertrophied and Failing Heart With Pressure Overload

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Population

Dahl salt-sensitive rats with hypertension-induced left ventricular hypertrophy and congestive heart…

Comparison

Hypertension-induced mechanical overload vs Age-matched Dahl salt-resistant (DR) rats

Design

Preclinical

Authors

AMAkira MatsumoriKanazawa UniversityYKYasuki KiharaGeneral CardiologyMIMoriaki InokoGeneral Cardiology

Discussion

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Implication

Proinflammatory upregulation marks overload-induced remodeling in rats; hypothesis-generating for cytokine-targeted therapies in human HF.

Structured PICO

P
Population
Dahl salt-sensitive (DS) rats with hypertension-induced left ventricular hypertrophy and congestive heart failure, and age-matched Dahl salt-resistant (DR) rats
I
Intervention
Hypertension-induced mechanical overload
C
Comparator
Age-matched Dahl salt-resistant (DR) rats
O
Outcome
Expression of interleukin (IL)-1 beta and monocyte chemotactic and activating factor (MCAF)/monocyte chemoattractant protein-1 (MCP-1) in the left ventriclesurrogate

Increased expression of proinflammatory cytokines and chemokines, along with macrophage infiltration, are associated with the pathogenesis of cardiac hypertrophy and failure induced by chronic mechanical overload in a rat model.

Cite This Study

Matsumori et al. (1997) studied this question.

synapsesocial.com/papers/6a7cb2c73a55089429770abehttps://doi.org/10.1161/01.res.81.5.664

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interleukin-1 beta modulates the growth and phenotype of neonatal rat cardiac myocytes.1995 · 274 citations
  2. 2Tumor necrosis factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration.1995 · 439 citations
  3. 3G protein-mediated suppression of L-type Ca2+ current by interleukin-1 beta in cultured rat ventricular myocytes1995 · 119 citations
  4. 4Activation of human peripheral monocytes by angiotensin II1994 · 210 citations
  5. 5Tissue Renin-Angiotensin System in Myocardial Hypertrophy and Failure1993 · 245 citations