February 11, 2011Circulation ResearchOpen Access

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

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Why the study?

Does overexpression of catalase targeted to mitochondria prevent angiotensin II-induced cardiac hypertrophy and Gαq overexpression-induced heart failure in mouse models?

Population

Genetic mouse models and cardiomyocytes

Comparison

Overexpression of catalase targeted to… vs Overexpression of wild-type peroxisomal catalase

Design

Preclinical

Authors

DDDao‐Fu DaiJohns Hopkins University SJSimon C. JohnsonNorthumbria University JVJason J. VillarinUniversity of Louisville

Discussion

Member takes

Implication

Mitochondrial-targeted antioxidants merit testing in hypertensive cardiomyopathy models; hypothesis-generating and leaves open human translation.

Structured PICO

Does overexpression of catalase targeted to mitochondria prevent angiotensin II-induced cardiac hypertrophy and Gαq overexpression-induced heart failure in mouse models?

Population

Genetic mouse models (mice overexpressing catalase targeted to mitochondria and to peroxisomes, mice with Gαq overexpression, mice with homozygous mutation of mitochondrial polymerase γ) and cardiomyocytes

Intervention

Overexpression of catalase targeted to mitochondria

Comparator

Overexpression of wild-type peroxisomal catalase

Outcome

Cardiac hypertrophy, fibrosis, mitochondrial damage, and heart failuresurrogate

Mitochondrial reactive oxygen species play a critical causal role in cardiac hypertrophy and failure, supporting the potential use of mitochondrial-targeted antioxidants for hypertensive cardiomyopathy.

Cite This Study

Dai et al. (2011) studied this question.

synapsesocial.com/papers/6a7cb3f50d1c97f421a8b36e https://doi.org/10.1161/circresaha.110.232306

Topics

Heart failure HFrEF treatment

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Implication

Mitochondrial-targeted antioxidants merit testing in hypertensive cardiomyopathy models; hypothesis-generating and leaves open human translation.

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider