In a transgenic mouse model, overexpressed catalase localizes to the sarcoplasm, nucleus, and peroxisomes of cardiomyocytes, but not mitochondria, providing insight into its role in myocardial oxidative injury.
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Localization in transgenic mouse hearts extends basic oxidative stress insights; leaves open mitochondrial catalase roles and any clinical translation.
Zhou et al. (2000) studied this question.
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