Why the study?
Does cardiac-specific overexpression of metallothionein prevent doxorubicin-induced cardiotoxicity in mice?
Population
7-week-old FVB transgenic mice with heart-specific overexpression of the human metallothionein-IIa gene and…
Comparison
Cardiac-specific overexpression of… vs Nontransgenic control mice treated with the same…
Design
Preclinical, Operators were unaware of the transgenic and doxorubicin…
Follow-up
4 days
Authors
Loading...
MT overexpression protects against doxorubicin cardiotoxicity in mice; leaves open translation to human anthracycline cardiomyopathy prevention.
Does cardiac-specific overexpression of metallothionein prevent doxorubicin-induced cardiotoxicity in mice?
Cardiac-specific overexpression of metallothionein in transgenic mice provides direct in vivo protection against doxorubicin-induced cardiotoxicity, supporting the free radical hypothesis of anthracycline toxicity.
Kang et al. (1997) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: