Key result
Vascular smooth muscle cell-specific overexpression of catalase dramatically attenuated angiotensin II-induced aortic wall hypertrophy (wall thickness 32.4 vs 43.2 microm; P<0.001).
Why the study?
Does vascular smooth muscle cell-specific catalase overexpression prevent angiotensin II-induced hypertension and vascular hypertrophy in mice?
Population
Transgenic mice with vascular smooth muscle cell-specific overexpression of the human catalase gene, and…
Comparison
Angiotensin II treatment in catalase transgenic… vs Angiotensin II treatment in control animals
Design
Preclinical
Authors
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Attenuates hypertrophy without blood pressure effect in mice; extends mechanistic insights but leaves open clinical relevance.
Does vascular smooth muscle cell-specific catalase overexpression prevent angiotensin II-induced hypertension and vascular hypertrophy in mice?
Absolute Event Rate: 32.4% vs 43.2%
p-value: p=<0.001
Vascular smooth muscle cell-derived hydrogen peroxide plays a critical role in angiotensin II-induced arterial wall hypertrophy, but not in the hypertensive response.
Zhang et al. (2005) studied Angiotensin II-induced hypertension and vascular hypertrophy. Vascular smooth muscle cell-specific overexpression of the human catalase gene vs. Control animals was evaluated on Aortic wall thickness (p=<0.001). Vascular smooth muscle cell-specific overexpression of catalase dramatically attenuated angiotensin II-induced aortic wall hypertrophy (wall thickness 32.4 vs 43.2 microm; P<0.001).
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