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August 8, 2005Journal of Hypertension

Vascular but not cardiac remodeling is associated with superoxide production in angiotensin II hypertension

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Why the study?

Does Angiotensin II-induced hypertension increase reactive oxygen species production in cardiac and vascular tissues in Sprague-Dawley rats?

Population

Sprague-Dawley rats (n=14)

Comparison

Angiotensin II 0.7 mg/kg per day by mini-pump… vs Vehicle

Design

Preclinical

Follow-up

5 days

Authors

MZMing-Sheng ZhouEJEdgar A. JaimesLRLeopoldo Raij

Discussion

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Overview

Ang II rat data suggest ROS-independent cardiac hypertrophy via calcineurin; hypothesis-generating for tissue-specific pathways, no clinical implications yet.

Structured PICO

Does Angiotensin II-induced hypertension increase reactive oxygen species production in cardiac and vascular tissues in Sprague-Dawley rats?

P
Population
Sprague-Dawley rats (n=14)
I
Intervention
Angiotensin II 0.7 mg/kg per day by mini-pump for 5 days
C
Comparator
Vehicle
O
Outcome
Superoxide (O2) production, endothelium-dependent relaxation (EDR), and tissue remodeling in aortas, mesenteric arteries, and heartsurrogate

In Angiotensin II-induced hypertension, vascular remodeling is driven by reactive oxygen species, whereas cardiac hypertrophy is mediated by calcineurin rather than ROS.

Cite This Study

Zhou et al. (2005) studied this question.

synapsesocial.com/papers/6a725ebfa528af2d65c466c2https://doi.org/10.1097/01.hjh.0000179513.71018.09
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: Effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation2005 · 81 citations
  2. 2In Salt-Sensitive Hypertension, Increased Superoxide Production Is Linked to Functional Upregulation of Angiotensin II2003 · 117 citations
  3. 3Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy2000 · 297 citations
  4. 4Angiotensin-Converting Enzyme Inhibition With Quinapril Improves Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease1996 · 1,058 citations
  5. 5Pivotal Role of a gp91 <sup>phox</sup> -Containing NADPH Oxidase in Angiotensin II-Induced Cardiac Hypertrophy in Mice2002 · 528 citations