Fixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka

n=700 adults with mild to moderate hypertension (systolic BP >140 mm Hg and/or diastolic BP >90 mm Hg; or >130/80 mm Hg in diabetes/CKD) requiring initiation or escalation of antihypertensive therapy. Mean age 56 years, 58% women, 29% diabetes. Enrolled from 11 urban hospital clinics in Sri Lanka.

Once-daily fixed-dose triple combination pill (20 mg telmisartan, 2.5 mg amlodipine, and 12.5 mg chlorthalidone)

Usual care

Proportion achieving target systolic/diastolic BP (<140/90 mm Hg or <130/80 mm Hg in patients with diabetes or chronic kidney disease) at 6 monthssurrogate