Persistent Infection with Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus in Apparently Healthy Homosexual Men

Brief Reports1 May 1985Persistent Infection with Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus in Apparently Healthy Homosexual MenHAROLD W. JAFFE, M.D., PAUL M. FEORINO, Ph.D., WILLIAM W. DARROW, Ph.D., PAUL M. O'MALLEY, B.A., JANE P. GETCHELL, Dr.P.H., DONNA T. WARFIELD, B.S., BONNIE M. JONES, B.S., DEAN F. ECHENBERG, M.D., Ph.D., DONALD P. FRANCIS, M.D., JAMES W. CURRAN, M.D.HAROLD W. JAFFE, M.D., PAUL M. FEORINO, Ph.D., WILLIAM W. DARROW, Ph.D., PAUL M. O'MALLEY, B.A., JANE P. GETCHELL, Dr.P.H., DONNA T. WARFIELD, B.S., BONNIE M. JONES, B.S., DEAN F. ECHENBERG, M.D., Ph.D., DONALD P. FRANCIS, M.D., JAMES W. CURRAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-5-627 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe acquired immunodeficiency syndrome appears to be caused by a retrovirus called both lymphadenopathy-associated virus (LAV) and human T-lymphotropic virus type III (HTLV-III) (1, 2). Several surveys have shown serologic evidence of infection with this virus in healthy persons from groups at increased risk for the acquired immunodeficiency syndrome (3). Because relatively little is known about the natural history of infection with this virus in such persons, we studied a group of apparently healthy homosexual men with serologic evidence of HTLV-III/LAV infection to determine the duration of their seropositivity, their immunologic status, and the frequency of isolation of HTLV-III/LAV from...References1. BARRÉ-SINOUSSICHERMANNREY FJF. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. 1983;220:868-71. CrossrefMedlineGoogle Scholar2. GALLOSALAHUDDINPOPOVIC RSM. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 1984;224:500-3. CrossrefMedlineGoogle Scholar3. Antibodies to a retrovirus etiologically associated with acquired immunodeficiency syndrome (AIDS) in populations with increased incidences of the syndrome. MMWR. 1984;33:377-9. MedlineGoogle Scholar4. ROGERSMORENSSTEWART MDJ. National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: Part 2, laboratory results. Ann Intern Med. 1983;99:151-8. LinkGoogle Scholar5. FEORINOKALYANARAMANHAVERKOS PVH. Lymphadenopathy associated virus infection of a blood donor-recipient pair with acquired immunodeficiency syndrome. Science. 1984;225:69-72. CrossrefMedlineGoogle Scholar6. MELBYEBIGGAREBBESEN MRP. Seroepidemiology of HTLV-III antibody in Danish homosexual men: prevalence, transmission, and disease outcome. Br Med J [Clin Res]. 1984;289:573-5. CrossrefMedlineGoogle Scholar7. GOEDERTSARNGADHARANBIGGAR JMR. Determinants of retrovirus (HTLV-III) antibody and immunodeficiency conditions in homosexual men. Lancet. 1984;2:711-6. CrossrefMedlineGoogle Scholar8. Provisional Public Health Service inter-agency recommendations for screening donated blood and plasma for antibody to the virus causing acquired immunodeficiency syndrome. MMWR. 1985;34:1-5. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Centers for Disease Control Atlanta, Georgia Department of Public Health San Francisco, California. 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CURRAN, M.D., M.P.H.The Epidemiology of AIDS: Current Status and Future ProspectsGenomic Diversity of Human T-Lymphotropic Virus Type III (HTLV-III) 1 May 1985Volume 102, Issue 5Page: 627-628KeywordsAIDSHIVHomosexualsHuman t lymphotropic virusInfectious disease controlInfectious disease immunologyLymphadenopathy associated virusNatural history of diseaseRetrovirusesSpecimen preparation and treatment ePublished: 1 December 2008 Issue Published: 1 May 1985 PDF downloadLoading ...