Why the study?
Intimal thickness plays a vital role in atherosclerotic changes, may vary across different parts of the aorta, and may increase with age.
Intimal thickness of the ascending aorta increases with age uniformly across segments, serving as an early histological marker of aging and atherosclerotic changes.
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No significant difference in aortic intimal thickness; leaves open age- and segment-related atherosclerotic mechanisms for prospective study.
Background: Intimal thickness is the innermost layer of aorta; play a vital role in development of atherosclerotic changes. It may vary in the different parts of the aorta and may increase with age. Methods: 120 aortas of adult human forensic bodies were taken. Histological slides were formed and the thickness of different segments of aorta were measured microscopically. Data were statically analyzed using ANOVA, p test methods. Results and Discussion: There is no significant difference of Intimal thickness in different segments of ascending aorta though it significantly increase with age may be due to accumulation of medial SMCs into intima. Results agree with previous workers. Conclusion: No significant difference between different segments of ascending aorta and it increase with age showing the aging aorta and early sign of atherosclerotic changes.
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Pahuja et al. (2021) studied this question.
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