Why the study?
Do catecholamines modulate protein turnover and cellular hypertrophy in cultured, quiescent rabbit cardiac myocytes?
Population
Cultured, quiescent rabbit ventricular myocytes (cultured for 1 week)
Comparison
Exposure to alpha- and/or beta-adrenergic agonists vs Unexposed cells or cells treated with specific…
Design
Preclinical
Follow-up
48 hours
Authors
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Should not alter catecholamine use in patients; hypothesis-generating for myocyte protein turnover in cardiac remodeling.
Do catecholamines modulate protein turnover and cellular hypertrophy in cultured, quiescent rabbit cardiac myocytes?
Catecholamine-induced hypertrophy in quiescent cardiac myocytes is associated with altered protein turnover and myofibrillar disruption.
Decker et al. (1993) studied this question.
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