Use of the multiple copy simultaneous search (MCSS) method to design a new class of picornavirus capsid binding drugs
Population
Computational models of the binding pocket of P3/Sabin poliovirus and rhinovirus 14
Comparison
Combinatorial ligand design approach based on… vs Known drugs
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports MCSS for picornavirus ligand design; leaves open experimental validation and clinical translation.
Structured PICO
P
Population
Computational models of the binding pocket of P3/Sabin poliovirus and rhinovirus 14
I
Intervention
Combinatorial ligand design approach based on the multiple copy simultaneous search (MCSS) method
C
Comparator
Known drugs
O
Outcome
Estimated binding strength
The MCSS method can be used to computationally design novel ligands that show promising estimated binding strengths to picornavirus capsids.
Cite This Study
Joseph‐McCarthy et al. (1997) studied this question.