Why the study?
Does a first-line strategy of single-pill perindopril/amlodipine improve blood pressure reduction compared to a stepped-care strategy starting with valsartan monotherapy in patients with mild to moderate hypertension?
Does a first-line strategy of single-pill perindopril/amlodipine improve blood pressure reduction compared to a stepped-care strategy starting with valsartan monotherapy in patients with mild to moderate hypertension?
Initiation of hypertension treatment with a single-pill combination of perindopril/amlodipine provides faster and greater blood pressure reduction compared to a stepped-care approach starting with valsartan monotherapy.
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Favors initial single-pill perindopril/amlodipine for faster BP control in mild-moderate hypertension; extends evidence for first-line combination over stepped-care strategies.
Mancia et al. (2014) studied this question.
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