June 1, 2000World Journal of Surgery
Manipulation of the Metabolic Response in Clinical Practice
Why the study?
How do various interventions modify the endocrine metabolic and inflammatory responses to surgical injury?
Population
Patients undergoing surgery (elective and severe surgical illness)
Design
Review
Authors
Discussion
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Member takes
Implication
May support ERAS integration in elective surgery; leaves open procedure-specific optimization in prospective trials.
Structured PICO
How do various interventions modify the endocrine metabolic and inflammatory responses to surgical injury?
P
Population
Patients undergoing surgery (elective and severe surgical illness)
I
Intervention
Techniques to modify stress responses including continuous epidural local anesthetics, NSAIDs, opioids, high-dose glucocorticoids, and minimally invasive surgery
O
Outcome
Endocrine metabolic response, inflammatory/immunologic responses, and postoperative morbidity
Modifying the stress response to surgery through neural blockade and minimally invasive techniques can improve postoperative outcomes, particularly in elective settings.
Cite This Study
Henrik Kehlet (2000) studied this question.