December 1, 2021BMC Pulmonary MedicineOpen Access

Vascular involvement in chronic thromboembolic pulmonary hypertension is associated with spirometry obstructive impairment

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Why the study?

CTEPH patients often show obstructive ventilatory impairment even without a smoking history, but the underlying mechanism remains unknown.

Population

135 CTEPH patients without a smoking history evaluated during admission for right heart catheterization

Design

Retrospective study

Authors

AYAsako YanagisawaJapan Community Healthcare Organization ANAkira NaitoChiba University TJTakayuki JujoNational Institute of Biomedical Innovation, Health and Nutrition

Discussion

Member takes

Implication

Vascular obstruction score independently predicts lower FEV1 in nonsmoking CTEPH; leaves open whether relieving vascular burden improves spirometry.

Structured PICO

Population

135 patients with chronic thromboembolic pulmonary hypertension (CTEPH) (defined as mean pulmonary arterial pressure of 25 mmHg and pulmonary capillary wedge pressure <15 mmHg on right heart catheterization), median age 64, 108 female / 27 male, at a single center in Japan. Key exclusion: patients with a smoking history.

Outcome

Correlation between %FEV1.0 and CT Angiogram (CTA) obstruction score, mean pulmonary artery pressure (mPAP), and pulmonary vascular resistance (PVR)surrogate

In patients with chronic thromboembolic pulmonary hypertension without a smoking history, spirometry obstructive impairment (%FEV1.0) is independently associated with the severity of pulmonary vascular obstruction.

Limitations

Retrospective, single-center, observational study
Unable to clarify the detailed mechanism underlying the respiratory function changes because pathological analyses were not performed

Cite This Study

Yanagisawa et al. (2021) studied this question.

synapsesocial.com/papers/6a7cbfe8b7ca9b673b7cd649 https://doi.org/10.1186/s12890-021-01779-x

Topics

Pulmonary embolism

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December 1, 2021BMC Pulmonary MedicineOpen Access

Vascular involvement in chronic thromboembolic pulmonary hypertension is associated with spirometry obstructive impairment

View Full Paper

Ask AI

Bookmark

Why the study?

CTEPH patients often show obstructive ventilatory impairment even without a smoking history, but the underlying mechanism remains unknown.

Population

135 CTEPH patients without a smoking history evaluated during admission for right heart catheterization

Design

Retrospective study

Authors

AYAsako YanagisawaJapan Community Healthcare Organization ANAkira NaitoChiba University TJTakayuki JujoNational Institute of Biomedical Innovation, Health and Nutrition

Discussion

Member takes

Implication

Vascular obstruction score independently predicts lower FEV1 in nonsmoking CTEPH; leaves open whether relieving vascular burden improves spirometry.

Structured PICO

Population

Outcome

Correlation between %FEV1.0 and CT Angiogram (CTA) obstruction score, mean pulmonary artery pressure (mPAP), and pulmonary vascular resistance (PVR)surrogate

Limitations

Retrospective, single-center, observational study
Unable to clarify the detailed mechanism underlying the respiratory function changes because pathological analyses were not performed

Cite This Study

Yanagisawa et al. (2021) studied this question.

synapsesocial.com/papers/6a7cbfe8b7ca9b673b7cd649 https://doi.org/10.1186/s12890-021-01779-x

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Pulmonary embolism

View Full Paper

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