November 4, 2010Virology JournalOpen Access

Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008

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Population

900 serum samples collected from children ≤5 years of age in 2005 from 6 different geographical areas in…

Design

Cross-sectional

Authors

ZZZhen ZhuNebraska Medical Center SZShuangli ZhuSun Yat-sen University XGXue-Bin GuoQinghai Institute for Endemic Diease Prevention and Control

Discussion

Member takes

Implication

Seroprevalence indicates pre-2008 endemic circulation of EV71 and CVA16; hypothesis-generating for outbreak emergence factors.

Structured PICO

Population

900 serum samples collected from children ≤5 years of age in 2005 from 6 different geographical areas (Anhui, Guangdong, Hunan, Xinjiang, Yunnan, and Heilongjiang provinces) in mainland China

Outcome

Positive rate and geometric mean titer (GMT) of HEV71 and CVA16 neutralizing antibodiessurrogate

HEV71 and CVA16 were widely circulating in several Chinese provinces prior to the large-scale outbreaks starting in 2008.

Cite This Study

Zhu et al. (2010) studied this question.

synapsesocial.com/papers/6a7cbfefa84850a1a3a8b6ba https://doi.org/10.1186/1743-422x-7-300

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Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider