What question did this study set out to answer?

To determine whether mild cognitive impairment represents early-stage Alzheimer disease by evaluating its long-term clinical progression and underlying neuropathologic features.

March 1, 2001Archives of Neurology

Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease

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Authors

MSMartha Storandt JMJ. Philip Miller DMDaniel W. McKeel

Discussion

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Overview

Prospective study reveals high dementia progression and Alzheimer neuropathology in older adults with mild cognitive impairment, indicating it represents early-stage Alzheimer disease.

Key Points

To determine whether mild cognitive impairment represents early-stage Alzheimer disease by evaluating its long-term clinical progression and underlying neuropathologic features.
Conducted a prospective study following community-living elderly volunteers (N = 454; mean age: 78.9 years for CDR 0, 76.9 years for CDR 0.5) for up to 9.5 years with postmortem neuropathologic examinations.
Stratified participants with Clinical Dementia Rating (CDR) scores of 0.5 (n = 277) into three subgroups based on diagnostic certainty: CDR 0.5/DAT, CDR 0.5/incipient DAT, and CDR 0.5/uncertain dementia, comparing them to healthy controls (CDR 0; n = 177).
At 5 years, progression rates to CDR 1 or greater were 60.5% (95% CI, 50.2%-70.8%) for CDR 0.5/DAT, 35.7% (95% CI, 21.0%-50.3%) for CDR 0.5/incipient DAT, 19.9% (95% CI, 8.0%-31.8%) for CDR 0.5/uncertain dementia, and 6.8% (95% CI, 2.2%-11.3%) for CDR 0 controls.
Survival analysis showed that 100% of participants with CDR 0.5/DAT progressed to greater dementia severity over 9.5 years, with progression rate correlating with baseline impairment severity.
Neuropathologic evaluation revealed dementing disorders in 24 of 25 autopsied participants with baseline CDR 0.5 scores, with 21 of 25 (84%) confirmed to have Alzheimer disease.

Cite This Study

Storandt et al. (2001) studied this question.

synapsesocial.com/papers/6a7cbff73dbea9de81611b4e https://doi.org/10.1001/archneur.58.3.397

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March 1, 2001Archives of Neurology

Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease

View Full Paper

Ask AI

Bookmark

Authors

MSMartha Storandt JMJ. Philip Miller DMDaniel W. McKeel

Discussion

Member takes

Overview

Prospective study reveals high dementia progression and Alzheimer neuropathology in older adults with mild cognitive impairment, indicating it represents early-stage Alzheimer disease.

Key Points

To determine whether mild cognitive impairment represents early-stage Alzheimer disease by evaluating its long-term clinical progression and underlying neuropathologic features.
Conducted a prospective study following community-living elderly volunteers (N = 454; mean age: 78.9 years for CDR 0, 76.9 years for CDR 0.5) for up to 9.5 years with postmortem neuropathologic examinations.
Stratified participants with Clinical Dementia Rating (CDR) scores of 0.5 (n = 277) into three subgroups based on diagnostic certainty: CDR 0.5/DAT, CDR 0.5/incipient DAT, and CDR 0.5/uncertain dementia, comparing them to healthy controls (CDR 0; n = 177).
At 5 years, progression rates to CDR 1 or greater were 60.5% (95% CI, 50.2%-70.8%) for CDR 0.5/DAT, 35.7% (95% CI, 21.0%-50.3%) for CDR 0.5/incipient DAT, 19.9% (95% CI, 8.0%-31.8%) for CDR 0.5/uncertain dementia, and 6.8% (95% CI, 2.2%-11.3%) for CDR 0 controls.
Survival analysis showed that 100% of participants with CDR 0.5/DAT progressed to greater dementia severity over 9.5 years, with progression rate correlating with baseline impairment severity.
Neuropathologic evaluation revealed dementing disorders in 24 of 25 autopsied participants with baseline CDR 0.5 scores, with 21 of 25 (84%) confirmed to have Alzheimer disease.

Cite This Study

Storandt et al. (2001) studied this question.

synapsesocial.com/papers/6a7cbff73dbea9de81611b4e https://doi.org/10.1001/archneur.58.3.397

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