Why the study?
Simple fatty liver is known to be prognostic, requiring greater emphasis on liver fat quantification beyond traditional invasive histological evaluation.
Do non-invasive imaging methods accurately quantify liver steatosis in patients with non-alcoholic fatty liver disease?
Do non-invasive imaging methods accurately quantify liver steatosis in patients with non-alcoholic fatty liver disease?
Technological innovations in non-invasive imaging, such as MRI-PDFF and advanced ultrasound techniques, provide accurate quantification of liver steatosis, reducing the need for invasive liver biopsies in NAFLD patients.
Simple steatosis carries prognostic weight in NAFLD; leaves open optimal quantification methods for practice and trials.
Non-alcoholic fatty liver disease is currently the most common chronic liver disease, affecting up to 25% of the global population. Simple fatty liver, in which fat is deposited in the liver without fibrosis, has been regarded as a benign disease in the past, but it is now known to be prognostic. In the future, more emphasis should be placed on the quantification of liver fat. Traditionally, fatty liver has been assessed by histological evaluation, which requires an invasive examination; however, technological innovations have made it possible to evaluate fatty liver by non-invasive imaging methods, such as ultrasonography, computed tomography, and magnetic resonance imaging. In addition, quantitative as well as qualitative measurements for the detection of fatty liver have become available. In this review, we summarize the currently used qualitative evaluations of fatty liver and discuss quantitative evaluations that are expected to further develop in the future.
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Nogami et al. (2022) studied this question.
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