What question did this study set out to answer?

Review the clinical applications, limitations, and emerging advances of ultrasound, CT, and MRI modalities for detecting and quantifying hepatic steatosis.

May 3, 2018British Journal of Radiology

Liver fat imaging—a clinical overview of ultrasound, CT, and MR imaging

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Authors

YZYingzhen ZhangChina Medical University KFKathryn J. FowlerScripps Clinic Medical Group GHGavin HamiltonUniversity of California, San Diego

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Implication

Clinical review demonstrates imaging performance for hepatic steatosis, highlighting MRI proton-density fat fraction as the most accurate biomarker for therapy monitoring and trial endpoints.

Key Points

Review the clinical applications, limitations, and emerging advances of ultrasound, CT, and MRI modalities for detecting and quantifying hepatic steatosis.
Evaluated qualitative and quantitative capabilities of ultrasound, including conventional screening and newer quantitative ultrasound techniques.
Assessed unenhanced and dual-energy CT performance alongside radiation trade-offs for steatosis evaluation.
Appraised MRI proton-density fat fraction accuracy as a noninvasive biomarker for therapeutic response.
Conventional ultrasound effectively identifies abnormal morphology for screening but lacks sufficient sensitivity and specificity to guide or monitor therapy, though quantitative ultrasound shows promise.
Unenhanced CT quantifies moderate to severe steatosis but remains inaccurate for mild disease and involves ionizing radiation.
MRI proton-density fat fraction provides the highest accuracy and precision among noninvasive imaging biomarkers, establishing it as the preferred endpoint for clinical trials and therapy monitoring.

Cite This Study

Zhang et al. (2018) studied this question.

synapsesocial.com/papers/69e5ce34b97ca60ecd13c4df https://doi.org/10.1259/bjr.20170959

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Implication

Clinical review demonstrates imaging performance for hepatic steatosis, highlighting MRI proton-density fat fraction as the most accurate biomarker for therapy monitoring and trial endpoints.

Liver fat imaging—a clinical overview of ultrasound, CT, and MR imaging

Discussion

Member takes

Implication

Key Points

Cite This Study

Liver fat imaging—a clinical overview of ultrasound, CT, and MR imaging

Discussion

Member takes

Implication

Key Points

Cite This Study

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