November 6, 2012HypertensionOpen Access

The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice

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Population

C57BL/6 wild-type (WT) and Ca(v)β3(-/-) mice

Comparison

Angiotensin II (Ang II) infusion for 2 weeks vs Saline infusion (control)

Design

Preclinical

Follow-up

2 weeks

Authors

SKSujay V. KharadeSanofi (France)SSSwapnil K. SonkusareUniversity of Virginia ASAnup K. SrivastavaIndian Institute of Information Technology Allahabad

Discussion

Member takes

Implication

Attenuates Ang II hypertension in Ca(v)β3-knockout mice; hypothesis-generating for channel regulation but should not change clinical practice.

Structured PICO

Population

C57BL/6 wild-type (WT) and Ca(v)β3(-/-) mice

Intervention

Angiotensin II (Ang II) infusion for 2 weeks

Comparator

Saline infusion (control)

Outcome

Ca(v)1.2 channel expression and function in second-order mesenteric arteries, and systolic blood pressuresurrogate

The Ca(v)β3 subunit is a critical regulatory protein required to upregulate arterial Ca(v)1.2 channels and fully develop Ang II-dependent hypertension in mice.

Cite This Study

Kharade et al. (2012) studied this question.

synapsesocial.com/papers/6a7cc0b3ec6509d062ba602b https://doi.org/10.1161/hypertensionaha.112.197863

Topics

Hypertension management

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Implication

Attenuates Ang II hypertension in Ca(v)β3-knockout mice; hypothesis-generating for channel regulation but should not change clinical practice.

The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider