Why the study?
Cardiac calcified amorphous tumors are rare non-neoplastic formations that present diagnostic challenges.
Does surgical excision followed by anticoagulation and antiplatelet therapy prevent tumor recurrence in a young male patient with a left ventricular calcified amorphous tumor, coronary artery disease, and thrombophilia?
Does surgical excision followed by anticoagulation and antiplatelet therapy prevent tumor recurrence in a young male patient with a left ventricular calcified amorphous tumor, coronary artery disease, and thrombophilia?
This case report and literature review demonstrates that cardiac calcified amorphous tumors can develop rapidly within 6 months in patients with thrombophilia and coronary artery disease even without mitral annular calcification or renal disease, and complete surgical excision prevents recurrence over 3 years of follow-up.
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LV CAT may mimic masses during CAD monitoring; leaves open optimal diagnostic and management strategies.
Background: Cardiac calcified amorphous tumors (CATs) are rare non-neoplastic formations containing amorphous fibrinous material and calcifications. In our research, we present the case of a 42-year-old male patient who developed, during his 6-months monitoring for coronary artery disease, a left ventricular (LV) CAT raising diagnostic challenges. Methods: To gather additional information on CATs, we researched the international medical literature for scientific articles published with the full text in English, on PubMed, ResearchGate, Clarivate, and Google Scholar between 2020 and 2024. Results: Compared to most described cases, our patient was a young male, without mitral annular calcification or chronic renal disease, but he was suffering from chronic peripheral and coronary artery disease, and genetic testing revealed a higher risk for thromboembolic events. During 6 months, he developed a LV CAT of 4.5/3.5/3 cm. Although we found in the medical literature 16 case reports of patients with CAT, only six authors could specify a precise postoperative evolution of the CAT, most of them sustaining that if completely removed, it would not relapse, an aspect observed also in our patient during 3 years of follow-up. Conclusions: CATs are rare heart tumors with slow growth, but with a high embolization risk that raises diagnostic and therapeutic challenges.
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Streian et al. (2024) studied this question.
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