Population
Isolated adult rat ventricular myocytes
Design
Preclinical
Authors
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Adenylate cyclase is rate-limiting for cAMP in rat myocytes; extends G-protein stoichiometry data but leaves open human translation.
In rat ventricular myocytes, G-protein is present in large stoichiometric excess relative to receptors and effectors, with adenylate cyclase being the rate-limiting component for cAMP production.
Post et al. (1995) studied this question.
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